The relationship between snp-polymorphisms of the leptin gene and the development of fatty liver disease in dairy cows

This article shows the results of studies in course which a comparative aspect LEP polymorphism was studied subpopulations Holstein dairy cattle cows with fatty hepatosis and healthy animals. is first time such are being conducted. In this case, hepothesis about relationship genetic markers, particular leptin gene, risk developing progression liver disease model when determining frequency occurrence genotypes polymorphisms groups animals studied. The aim research to establish possible influence genotype at locus (polymorphisms Y7F, A80V, R25C) on cows. R25C, Y7F loci 180 were genotyped, where 80 diagnosed 100 healthy. group cows, compared pathology, RC (R25C polymorphism) significantly more frequent, CC polymorphism), contrary, much higher hepatosis. Similar trends noted for another (A80V).